药用植物研究所

韩美华研究员

韩美华，博士，研究员，博士生导师。博士毕业于北京大学药学院，中国医学科学院药用植物研究所博士后出站后，一直在制剂中心工作。近15年进行中药有效成分及有效部位以及化药的临床前研究。进行中药成分的提取、分离以及结构鉴定和制剂学载药研究。同时利用纳米技术改善难溶性药物溶解性和生物利用度以及进行体内外药效学评价，成功构建了20多种难溶性药物纳米粒和10多种肿瘤主动靶向纳米粒并系统的进行了评价。主要的研究方向包括：纳米技术改善脂溶性药物的溶解度及提高口服生物利用度；肿瘤主动和被动靶向的纳米给药系统；肿瘤的局部给药和光热治疗；新药及保健食品研发。主持国家自然科学基金和北京市自然科学基金项目多项；参与国家项目及重大项目10多项；主持横向课题多项，发表论文40余篇，其中SCI收录22余篇；一作授权专利2项。培养硕士研究生20余名。

邮箱 : hanmeihua727@163.com

工作电话 : 010-57833250

近5年研究项目

2021年参与中国医学科学院创新工程“中药生产主要环节外源污染物防控与质量监测提升关键技术研究”。

近5年代表性论文

[1]. Lina Sun, Baonan Ma, Cuiling Zuo, Xinxin Liu, Yu Xia, Xiangtao Wang, Yifei Guo*, Meihua Han*. Combination of chemotherapy with low-dose doxorubicin/Lycium barbarum polysaccharide and photothermal therapy with polypyrrole nanoparticles for treating breast cancer. Journal of Drug Delivery Science and Technology, 2023, 104442.

[2]. Lina Sun, Cuiling Zuo, Xinxin Liu, Yifei Guo, Xiangtao Wang, Zhengqi Dong* and Meihua Han*. Combined photothermal therapy and lycium barbarum polysaccharide for topical administration to improve the efficacy of doxorubicin in the treatment of breast cancer. Pharmaceutics, 2022, 14, 2677.

[3]. Cuiling Zuo, Yuan Zou, Guangyu Gao, Lina Sun, Bo Yu, Yifei Guo, Xiangtao Wang*, Meihua Han,* Photothermal combined with intratumoral injection of annonaceous acetogenin nanoparticles for breast cancer therapy. Colloids and Surfaces B: Biointerfaces, 2022, 213, 112426.

[4]. Jianwei Han, Xinxin Zhou, Jingxin Fu, Guangyu Gao, Cuiling Zuo, Yifei Guo, Meihua-Han*, Xiangtao Wang*. Annonaceous acetogenins nanosuspensions stabilized by poloxamer 188: Preparation, properties and in vivo evaluation. Journal of Drug Delivery Science and Technology, 2021, 66, 102676.

[5]. Yuan Zou, Xiangtao Wang, Dongdong Bi, Jingxin Fu, Jianwei Han, Yifei Guo, Li Feng, Meihua Han. Pterostilbene nanoparticles with small particle size show excellent anti-breast cancer activity in vitro and in vivo. Nanotechnology, 2021, 32, 325102 (9pp).

[6]. Mengying Zhang, Yuan Zou, Cuiling Zuo, Hui Ao, Yifei Guo, Xiangtao Wang, Meihua Han. Targeted antitumor comparison study between dopamine self- polymerization and traditional synthesis for nanoparticle surface modification in drug delivery. Nanotechnology, 2021, 32, 305102 (11pp).

[7]. Qi Xiao-Yu, Liu Hao, Bi Dong-Dong, Wang Xiang-Tao, Guo Yi-Fei, Hao Ting, Zhang Bao-Xin, Wang Xing-Guo,?, Han Mei-Hua?. Combined administration on You-Gui Yin and low-dose Raloxifene partially attenuates the bone loss in ovariectomized mice through the proliferation and osteogenic differentiation of bone marrow stromal cells. Phytomedicine, 2019, 53, 286.

[8]. Zhao Lei, Zhang Mengyinga, Guo Yifei, Wang Xiangtao*, Han Meihua*. Alendronate-modified polydopamine-coated paclitaxel nanoparticles for osteosarcoma-targeted therapy. Journal of Drug Delivery Science and Technology, 2019, 53, 101133.

[9]. Lei. Zhao#, Dongdong. Bi#, Xiaoyu. Qi, Yifei. Guo, Xiangtao. Wang* and Meihua. Han* Polydopamine-based surface modification of paclitaxel nanoparticles for osteosarcoma targeted therapy. Nanotechnology, 2019, 30(25): 255101.

[10]. Dongdong Bi, Lei Zhao, Haowen Li, Yifei Guo, Xiangtao Wang?, Meihua Han?. A comparative study of polydopamine modified and conventional chemical synthesis method in doxorubicin liposomes form the aspect of tumor targeted therapy. International Journal of Pharmaceutics, 2019, 559: 76.

[11]. Runqi Yu, Yuan Zou, Biao Liu，Yifei Guo, Xiangtao Wang?, Meihua Han?. Surface modification of pH-sensitive honokiol nanoparticles based on dopamine coating for targeted therapy of breast cancer. Colloids and Surfaces B: Biointerfaces, 2019, 177: 1.

授权专利