博士生导师 分析中心副主任

研究方向：中药质量控制与分析，中药外源性污染物与安全性研究。

联系方式：mhyang@implad.ac.cn

现为中国医学科学院药用植物研究所分析中心副主任兼任海南分所副所长。任中国医学科学院药用植物研究所学术和学位委员会委员。获得国务院政府特殊津贴。荣获2009、2010、2012年药植所突出贡献奖，2014年度被评为药植所先进个人。主持或参与国家科技部重大新药创制专项、中医药行业科研专项、国家科技支撑计划、国家自然科学基金、北京市自然科学基金等课题20多项。曾赴美国、英国、芬兰、意大利等国做学术交流和访问。

主编协和研究生教材《中药质量控制与分析》和《中药中真菌及真菌毒素污染研究与对策》专著，参编著作4部，在国内外杂志发表论文340多篇，其中SCI文章140多篇。作为提案人，制定并发布ISO国际标准2项；研制团体标准4项，其中已发布2项。至目前为止，培养博士后、博士、硕士（包括联合培养生）共计90多人，其中多人获得国家奖学金以及校优秀论文。

近3年承担课题

1、国家自然科学基金面上项目“基于“TF-AuNCs-NFsM”微集成自净化免疫传感新技术用于中药材中新烟碱类农药多残留快速检测研究”（82173971，2022.01-2025.12）

2、北京市自然科学基金面上项目“新烟碱类农药在三七中的分布累积规律及传导机制研究”（7222287，2022.01-2024.12）

3、北京协和医学院2021年研究生课程信息化项目“《中药质量控制与分析》慕课课程建设”（2021YXX010，2022.01-2023.12）

4、高端外国专家引进计划“中药质量控制关键技术及国际标准研究”（G2021194003L，2021.01-2022.12）

5、上饶市科学技术局2021年市级科技专项项目“肠炎宁片中药大品种工艺优化及临床循证医学研究”（2021A002，2022.01-2023.12）

6、中国医学科学院医学与健康科技创新工程“中药生产主要环节外源污染物防控与质量监测提升关键技术研究”（2021-I2M-1-071，2021/10-2025/12）

近3年发表文章

1.QianLu, Ming Sui, Ya-Wen Luo, Jiao-Yang Luo*, Mei-Hua Yang*. Furtherinsight intothe potential toxicity of zearalenone-14-glucoside based ontoxicokinetics,tissue distribution, transformation, and excretion in rats.Ecotoxicologyand Environmental Safety, 2022, 246, 114184.https://doi.org/10.1016/j.ecoenv.2022.114184

2.HaonanRuan, Qian Lu, Jiashuo Wu, Jiaan Qin, Ming Sui, Xinqi Sun, YueShi*, JiaoyangLuo*, Meihua Yang*. Hepatotoxicity of food-borne mycotoxins:molecularmechanism, anti-hepatotoxic medicines and target prediction.CriticalReviews in Food Science and Nutrition, 2022, 62(9), 2281–2308.https://doi.org/10.1080/10408398.2021.1960794

3.YunyunWang, Haonan Ruan, Jing Zhang, Yudan Wang, Mengyue Guo, Tongwei Ke,JiaoyangLuo*, Meihua Yang*. CHA-based dual signal amplificationimmunofluorescencebiosensor for ultrasensitive detection of dimethomorph.Analytica ChimicaActa, 2022, 1227, 340323.https://doi.org/10.1016/j.aca.2022.340323

4.QianLu, Jiao-Yang Luo, Hao-Nan Ruan, Chang-Jian Wang, Mei-HuaYang*.Structure-toxicity relationships, toxicity mechanisms and healthriskassessment of food-borne modified deoxynivalenol and zearalenone:Acomprehensive review. Science of the Total Environment, 2022, 806,151192.https://doi.org/10.1016/j.scitotenv.2021.151192

5.YudanWang,Cheng Zhang, Lei Zhang, Zhen OuYang, Ming Zhao, Jiaoyang Luo*,Meihua Yang*.The presence and transfer characteristics of aflatoxins inmedicinal herbs:From raw materials to edible dispensing granules. Journal ofSeparationScience, 2022, 45 (18), 3404–3411. DOI: 10.1002/jssc.202200420

6.YudanWang, Jia’ an Qin, Jing Zhang, Ziyue Jin, Jiaoyang Luo*, MeihuaYang*. Rapidscreening of imidacloprid residue in grains and medicinal herbs: Anewlydesigned hapten and monoclonal antibody. Journal of PharmaceuticalandBiomedical Analysis, 2022, 219, 114931.https://doi.org/10.1016/j.jpba.2022.114931

7.HaonanRuan, Yunyun Wang, Yong Hou, Jing Zhang, Jiashuo Wu, FangqingZhang, Ming Sui,Jiaoyang Luo*, Meihua Yang*. Zearalenone-14-Glucoside IsHydrolyzed toZearalenone by β-Glucosidase in Extracellular Matrix to ExertIntracellular Toxicityin KGN Cells. Toxins, 2022, 14, 458.https://doi.org/10.3390/toxins14070458

8.YudanWang, Yanwei Fu, Yunyun Wang, Qian Lu, Haonan Ruan, Jiaoyang Luo*,MeihuaYang*. A comprehensive review on the pretreatment and detection methodsofneonicotinoid insecticides in food and environmental samples. FoodChemistry:X, 2022, 15, 100375. https://doi.org/10.1016/j.fochx.2022.100375

9.YanweiFu, Jing Zhang, Jiaan Qin, Xiaowen Dou, Jiaoyang Luo*, Meihua Yang*.Representativematrices for use in matrix-matched calibration in gaschromatography-massspectrometry for the analysis of pesticide residues indifferent types offood-medicine plants. Journal of Food Composition andAnalysis, 2022, 111,104617. https://doi.org/10.1016/j.jfca.2022.104617

10.Qian Lu, Meng-Yue Guo,Jiao Tian, Jiao-Yang Luo*, Mei-Hua Yang*. Acomprehensive study onmulti-mycotoxin screening, changes of mycotoxin residuesand fungal community analysisfrom barley germination to malt. International Journalof Food Microbiology,2022, 372, 109678.https://doi.org/10.1016/j.ijfoodmicro.2022.109678

11.Qian Lu, Hao-Nan Ruan,Xin-Qi Sun, Jiao-Yang Luo*, Mei-Hua Yang*.Contamination status and health riskassessment of 31 mycotoxins in six edibleand medicinal plants using a novelgreen defatting and depigmenting pretreatmentcoupled with LC-MS/MS. LWT - FoodScience and Technology, 2022, 161, 113401.https://doi.org/10.1016/j.lwt.2022.113401

12.Yihao Zhang, Xiaopei Wu,Wei Wang, Jianglian Huo, Jiaoyang Luo*, YouxuanXu*, Jianghai Lu*. Simultaneousdetection of 93 anabolic androgenic steroids indietary supplements using gaschromatography tandem mass spectrometry. Journalof Pharmaceutical andBiomedical Analysis, 2022, 211, 114619.https://doi.org/10.1016/j.jpba.2022.114619

13.Xinqi Sun, Jiaoyang Luo,Qian Lu, Chunyu Li, Zhigao Zhao, Fang An*, MeihuaYang*. Application ofhydroxylated multi-walled carbon nanotubes asdepigmentation agent in thedetermination of multiple pesticide residues inLonicerae japonicaeflower buds. Microchemical Journal, 2022, 177, 107280.https://doi.org/10.1016/j.microc.2022.107280

14.田娇, 安芳, 鹿倩, 孙新琪, 骆骄阳*, 杨美华*. 荧光适体传感器在食品中镰刀菌毒素检测的研究进展. 食品安全质量检测学报, 2022, 13 (15): 4974-4982. DOI:10.19812/j.cnki.jfsq11-5956/ts.2022.15.039

15.周蕾，为盼盼，韩文静，万河妨，江伟，骆骄阳*，隋春*. 不同产地柴胡的皂苷含量和ITS序列比较. 中国现代中药, 2022, 24(7),1279-1284. DOI: 10.13313/j.issn.1673-4890.20211011003

16.孙新琪, 安芳, 鹿倩, 李春雨, 骆骄阳*, 杨美华*. 我国中药材禁用农药残留现状、毒性及分析方法研究进展.中国中药杂志, 2022, 47(3),611-627.10.19540/j.cnki.cjcmm.20211014.202

17.Zhong-Ping Jiang, Shi-Hao Sun, Yi Yu, Attila Mándi, Jiao-Yang Luo,Mei-HuaYang, Tibor Kurtán*, Wen-Hua Chen*, Li Shen*, Jun Wu*. Discovery ofbenthol Aand its challenging stereochemical assignment: opening up a new windowforskeletal diversity of super-carbonchain compounds. Chemical Science,2021, 12,10197. DOI: 10.1039/d1sc02810c

18.Jia’an Qin, Qian Lu, Changjian Wang, Jiaoyang Luo*, Meihua Yang*.Colloidalgold-based lateral flow immunoassay with inline cleanup for rapidon-sitescreening of carbendazim in functional foods. Analytical andBioanalyticalChemistry, 2021 413, 3725–3735.https://doi.org/10.1007/s00216-021-03321-8

19.Changjian Wang, Lei Zhang, Jiaoyang Luo, Jiaan Qin, Jiayi Jiang, LuQin,Zhigao Zhao, Shihai Yang*, Meihua Yang*. Development of a sensitiveindirectcompetitive enzyme-linked immunosorbent assay for high-throughputdetection andrisk assessment of aflatoxin B1 in animal-derived medicines.Toxicon,2021, 197, 99–105. https://doi.org/10.1016/j.toxicon.2021.04.009

20.Tingting Sun, Jiaoyang Luo, Yuanyuan Xu, Xinqi Sun, Shihai Yang*, MeihuaYang*.Ultra-high performance supercritical fluid chromatography method forseparationand quantitation of saikosaponins in herbal medicine. Journal ofPharmaceuticaland Biomedical Analysis, 2021, 199, 114039.https://doi.org/10.1016/j.jpba.2021.114039

21.Zhigao Zhao, Xiaowen Dou, Jiaoyang Luo, Meiqi Jin, Jiaan Qin,ChangjianWang, Shihai Yang*, Meihua Yang*. Magnetic particles encoding asuspensionprobe for ultra-sensitive and quantitative determination of atrazine.Journalof Pharmaceutical and Biomedical Analysis, 2021, 195, 113868.https://doi.org/10.1016/j.jpba.2020.113868

22.金美奇，豆小文，付延伟，秦家安，骆骄阳，范卓文，杨美华*. 山楂常见有机氯、有机磷及拟除虫菊酯农药残留的膳食暴露研究. 世界科学技术-中医药现代化, 2020, 22(10), 3702-3710. DOI:10.11842/wst.20190530006

23.王长健, 骆骄阳, 秦家安, 张磊, 杨世海*, 杨美华*. 间接和直接竞争酶联免疫吸附法快速检测中药材中黄曲霉毒素B1的对比研究. 2021, 46(22), 5861-5866.DOI:10.19540/j.cnki.cjcmm.20210310.305

24.赵志高, 骆骄阳, 付延伟, 徐媛媛, 王长健, 杨世海*, 杨美华*. 免疫分析技术在农药残留分析中的研究进展及在中药中的应用展望. 分析测试学报, 2021, 40(1), 149-158.

25.徐媛媛, 骆骄阳, 孙婷婷, 赵志高, 杨世海*, 杨美华*. 杜仲药材国内外质量标准概述. 中国中药杂志, 2021, 46(14), 3577-3582.

26.Qian Lu, Jia-An Qin, Yan-Wei Fu, Jiao-Yang Luo*, Jiang-Hai Lu b*,AntonioF. Logrieco*, Mei-Hua Yang*. Modified mycotoxins in foodstuffs, animalfeed,and herbal medicine: A systematic review on global occurrence,transformationmechanism and analysis methods. Trends in Analytical Chemistry,2020, 133,116088. https://doi.org/10.1016/j.trac.2020.116088

27.Jia’an Qin, Yanwei Fu, Qian Lu, Xiaowen Dou, Jiaoyang Luo*, MeihuaYang*.Matrix-matched monitoring ion selection strategy for improving thematrixeffect and qualitative accuracy in pesticide detection based onUFLC-ESI-MS/MS:A case of Chrysanthemum. Microchemical Journal, 2021, 160,105681. https://doi.org/10.1016/j.microc.2020.105681