郭一飞，女，博士，研究员，硕士生导师。2009年06月博士毕业于郑州大学材料科学与工程学院，同年08月至中国医学科学院药用植物研究所工作，现任研究员。研究方向主要包括：①智能高分子药用载体的制备及与药物间相互作用的研究；②基于主客体相互作用的纳米吸附材料的设计及应用。通过研究工作的开展，发表相关SCI论文50余篇。授权专利5项。参编专著1本。主持有“中医药现代化研究”重点专项（课题负责人）、国家自然科学基金、海南省重点研发计划、北京协和医学院青年基金、所青年基金；参与中国医学科学院医学与健康科技创新工程课题、国家自然科学基金面上项目、北京市自然基金面上项目等。

邮箱 : ffguo@163.com

工作电话 : 010-57833250

获奖情况

2017年青年科研人员科研产出第一名

近5年研究项目

1. 2023年主持海南省重点研发项目“功能性脱除材料在巴戟天中重金属脱除的应用研究”。

2. 2018年主持国家重点研发计划中医药现代化研究重点专项课题“化橘红功能因子确定及大健康产品开发”。

3. 2022年参与中国医学科学院创新工程“药物研究院平台建设-基于系统论的创新药物研究体系建设”。

4. 2021年参与中国医学科学院创新工程“珍稀药用植物品质评价与资源保障关键技术研究”。

近5年代表性论文

[1]. Bo Yu, Xiaoxue Lang, Xiangtao Wang, Lijuan Ding, Meihua Han, Yifei Guo*, Zhengqi Dong*. Effects of different conformations of polylysine on the anti-tumor efficacy of methotrexate nanoparticles. Biomedicine Pharmacotherapy, 2023, 162, 114662.

[2]. Yansong Zhang, Lijuan Ding, Ting Wang, Xiangtao Wang, Bo Yu, Fei Jia, Meihua Han, Yifei Guo*. A celastrol drug delivery system based on PEG derivatives: The structural effects of nanocarriers. Molecules, 2023, 28, 1040.

[3]. Lujuan Ding, Xiangtao Wang, Ting Wang, Bo Yu, Meihua Han, Yifei Guo*. Effect of lipophilic chains on the antitumor effect of a dendritic nano drug delivery system. Molecules, 2023, 28, 69.

[4]. Bo Yu, Xiangtao Wang, Lijuan Ding, Meihua Han, Yifei Guo*. Hydrophilic natural polylysine as drug nanocarrier for preparation of helical delivery system. Pharmaceutics, 2022, 14, 2512.

[5]. Yifei Guo, Yiping Shen, Bo Yu, Lijuan Ding, Zheng Meng, Xiaotong Wang, Meihua Han, Zhengqi Dong* and Xiangtao Wang*. Hydrophilic poly(glutamic acid)-based nanodrug delivery System: Structural influence and antitumor efficacy. Polymers, 2022, 14, 2242.

[6]. Bo Yu, Yiping Shen, Xuejie Zhang, Lijuan Ding, Zheng Meng, Xiaotong Wang, Meihua Han, Yifei Guo* and Xiangtao Wang*. Poly(methacrylate citric acid) as a dual functional carrier for tumor therapy. Pharmaceutics, 2022, 14, 1765.

[7]. Zhengqi Dong, Xiangtao Wang, Mingyue Wang, Rui Wang, Zheng Meng, Xiaotong Wang, Bo Yu, Meihua Han and Yifei Guo*. Optimization of naringenin nanoparticles to improve the antitussive effects on post-infectious cough. Molecules, 2022, 27, 3736.

[8]. Zhengqi Dong, Rui Wang, Mingyue Wang, Zheng Meng, Xiaotong Wang, Meihua Han, Yifei Guo,* and XiangtaoWang,* Preparation of naringenin nanosuspension and its antitussive and expectorant effect. Molecules, 2022, 27, 741.

[9]. Zhengqi Dong, Hanhong Qiu, Meihua Han, Rui Wang, Yifei Guo*, Xiangtao Wang*. Honokiol-based nanomedicine decorated with ethylene glycols derivatives promotes antitumor efficacy. Journal of Biomedical Nanotechnology, 2021, 17(8), 1564-1573.

[10]. Haowen Li#, Biao Liu#, Hui Ao, Jingxin Fu, Yian Wang, Yue Feng, Yifei Guo* and Xiangtao Wang*. Soybean lecithin stabilizes disulfiram nanosuspensions with a high drug-loading content: remarkably improved antitumor efficacy. Journal of Nanobiotechnology, 2020, 18: 4.

[11]. Zhengqi Dong, Xiangtao Wang, Shuang Zhao, Hanhong Qiu, Meihua Han, Jingguo Li, Ning Zhao, Rui Wang, Yifei Guo. The influence of nanocarrier architectures on antitumor efficacy of docetaxel nanoparticles. RSC Advances, 2020, 10, 11074.

[12]. Zhengqi Dong, Yiping Shen, Shuang Zhao, Xiangtao Wang, Meihua Han, Ning Zhao, Hui Ao, Yifei Guo*. The influence of hydrophobic chains in nanocarriers on antitumor efficacy of docetaxel nanoparticles. Molecular Pharmaceutics, 2020, 17, 1205.

[13]. Xuejie Zhang#, Xiangtao Wang#, Hanhong Qiu, Dandan Kong, Meihua Han, Yifei Guo*. Poly(methacrylate citric acid) with good biosafety as nanoadsorbents of heavy metal ions. Colloids and Surfaces B: Biointerfaces, 187, 2020, 110656.

[14]. Xuejie Zhang#, Xiangtao Wang#, Hanhong Qiu, Xueqing Sun, Meihua Han, Yifei Guo*.. Nanoadsorbents preparing from oligoethylene glycol dendron and citric acid: Enhanced ad sorption effect for the removal of heavy metal ions. Colloids and Surfaces B: Biointerfaces, 189, 2020, 110876.

[15]. Yifei Guo, Xuejie Zhang, Xueqing Sun, Dandan Kong, Meihua Han, and Xiangtao Wang*. Nanoadsorbents based on NIPAM and citric acid: Removal efficacy of heavy metal ions in different media. ACS Omega, 2019, 4, 14162.

[16]. Yifei Guo, Ting Wang, Hanhong Qiu, Meihua Han, Zhengqi Dong?, Xiangtao Wang?, Hydroxycamptothecin nanoparticles based on poly/oligo (ethylene glycol): Architecture effects of nanocarriers on antitumor efficacy. European Journal of Pharmaceutics and Biopharmaceutics, 2019, 134: 178.

     授权专利

     1）郭一飞，孟征，王向涛. 一种以聚甲基丙烯酸羟乙酯为载体的柚皮苷纳米粒及其制备方法与应用，专利号：ZL202210050086.3

     2）郭一飞，孙雪晴，王向涛. 一种含有甲基丙烯酸2-吗啉基乙酯单体单元的聚合物及应用，专利号：ZL202011110734.7

     3）郭一飞，孙雪晴，王向涛. 一种含有2-羟甲基丙烯酸乙酯单体单元的聚合物及其制备方法与应用，专利号：ZL202011112322.7

     4）郭一飞，王明月，董政起，王向涛. 一种以TPGS为载体的柚皮素纳米混悬剂及其制备方法与应用，专利号：ZL202110407188.1

     5）郭一飞，沈一平，张雪洁，王向涛，韩美华. 一种以聚柠檬酸为载体的纳米载药颗粒及其制备方法与应用，专利号：ZL202011286955.X

     6）郭一飞，张雪洁，邱瀚弘，孔丹丹，王向涛. 一种含有柠檬酸甲基丙烯酸酯单体单元的聚合物及其在去除重金属离子中的应用，专利号：ZL201811443699.3