课题组负责人：石钺

课题组简介：课题组由1名研究员及研究生组成。课题组主要从事中药及复方的药效物质基础研究，包括基于体内过程的有效成分发现、质量标志物确定、配伍规律探索等相关研究。

研究方向：

1、  中药药效物质基础研究

2、  中药质量控制研究

3、  化妆品植物原料检测方法研究

近年发表的论文：

1.         Huanyu Guan, Pengfei Li, Qian Wang, Fanli Zeng, Jiashuo Wu, Fangqing Zhang, Shanggao Liao, Yue Shi*. Deciphering the chemical constituents of Shengjiang Xiexin decoction by ultrahigh-performance liquid chromatography-quadrupole/orbitrap high-resolution mass spectrometry and the impact of 20 characteristic components on multidrug resistance-associated protein 2 in the vesicular transport assay. J Sep Sci. 2022, 45, 3459-3479.

2.         Xiao-Yan Chang, Jia-Shuo Wu, Fang-Qing Zhang, Zhuang-Zhuang Li, Wei-Yi Jin, Jing-Xun Wang, Wei-Hua Wang, Yue Shi*. A Strategy for Screening the Lipid-Lowering Components in Alismatis Rhizoma Decoction Based on Spectrum-Effect Analysis. Journal of Analytical Methods in Chemistry. 2022, 2022: 2363242.

3.         Fangqing Zhang, Jiashuo Wu, Haonan Ruan, Jing Xia, Haotian Xue, Jingxun Wang, Qiuyue Li, Yue Shi*. ZeXie decoction alleviates non-alcoholic fatty liver disease in rats: the study of genes, lipids, and gut microbiotas. Biochem Biophys Res Commun. 2022, 632, 129-138.

4.         Shunliang Zheng, Yi Wang, Jiashuo Wu, Siyao Wang, Huaifu Wei, Yongchun Zhang, Jianbo Zhou* and Yue Shi*.Critical Quality Control Methods for a Novel Anticoagulant Candidate LFG-Na by HPSEC-MALLS-RID and Bioactivity Assays. Molecules. 2022, 27: 4522.

5.         Jiashuo Wu, Shunliang Zheng, Fangqing Zhang, Haonan Ruan, Haotian Xue, Jingxun Wang, Zhuangzhuang Li, Weiyi Jin, Weihua Wang, Jing Xia and Yue Shi*. Qualitative Analysis of Drug-Containing Plasma and its Application to Quantitative Analysis and Pharmacokinetic Study of Zexie Decoction Using UPLC-MS/MS. Frontiers in Chemistry. 2022, 10: 815886.

6.         Fangqing Zhang, Qiuyue Li, Jiashuo Wu, Haonan Ruan, Chuanrui Sun, Jia Zhu, Qinghui Song, Xu Wei*, Yue Shi* and Liguo Zhu*. Total Flavonoids of Drynariae Rhizoma Improve Glucocorticoid-Induced Osteoporosis of Rats: UHPLC-MS-Based Qualitative Analysis, Network Pharmacology Strategy and Pharmacodynamic Validation. Frontiers in Endocrinology. 2022, 13: 920931.

7.         Xiaoming Wang, Xiaoyao Chang, XiaomeiLuo, Meifeng Su, RongXu, Jun Chen, Yi Ding, Yue Shi*. An Integrated Approach to Characterize Intestinal Metabolites of Four Phenylethanoid Glycosides and Intestinal Microbe-Mediated Antioxidant Activity Evaluation In Vitro Using UHPLC-Q-Exactive High-Resolution Mass Spectrometry and a 1,1-Diphenyl-2-picrylhydrazyl-Based Assay. Frontiers in Pharmacology, 2019, 10: 826.

8.         Huanyu Guan, XiaomeiLuo, Xiaoyan Chang, Meifeng Su, Zhuangzhuang Li, Pengfei Li, Xiaoming Wang and Yue Shi*. Identification of the Chemical Constituents of an Anti-Arthritic Chinese Medicine Wen Luo Yin by Liquid Chromatography Coupled with Mass Spectrometry. Molecules 2019, 24: 233.