药用植物研究所

王向涛课题组发表文章

时间：2023-04-08 来源：

近5年代表性论文：

[1]. Lina Sun, Baonan Ma, Cuiling Zuo, Xinxin Liu, Yu Xia, Xiangtao Wang, Yifei Guo*, Meihua Han*. Combination of chemotherapy with low-dose doxorubicin/Lycium barbarum polysaccharide and photothermal therapy with polypyrrole nanoparticles for treating breast cancer. Journal of Drug Delivery Science and Technology, 2023, 104442.

[2]. Bo Yu, Xiaoxue Lang, Xiangtao Wang, Lijuan Ding, Meihua Han, Yifei Guo*, Zhengqi Dong*. Effects of different conformations of polylysine on the anti-tumor efficacy of methotrexate nanoparticles. Biomedicine Pharmacotherapy, 2023, 162, 114662.

[3]. Yansong Zhang, Lijuan Ding, Ting Wang, Xiangtao Wang, Bo Yu, Fei Jia, Meihua Han, Yifei Guo*. A celastrol drug delivery system based on PEG derivatives: The structural effects of nanocarriers. Molecules, 2023, 28, 1040.

[4]. Lujuan Ding, Xiangtao Wang, Ting Wang, Bo Yu, Meihua Han, Yifei Guo*. Effect of lipophilic chains on the antitumor effect of a dendritic nano drug delivery system. Molecules, 2023, 28, 69.

[5]. Kunfeng Zhang, Jingxin Fu, Xiaorui Liu, Yifei Guo, Meihua Han, Meifeng Liu,* and Xiangtao Wang*. Mitochondrial-Targeted triphenylphosphonium-yydroxycamptothecin conjugate and its nano-formulations for breast cancer therapy: In vitro and in vivo investigation. Pharmaceutics, 2023, 15, 138.

[6]. Lina Sun, Cuiling Zuo, Xinxin Liu, Yifei Guo, Xiangtao Wang, Zhengqi Dong* and Meihua Han*. Combined photothermal therapy and lycium barbarum polysaccharide for topical administration to improve the efficacy of doxorubicin in the treatment of breast cancer. Pharmaceutics, 2022, 14, 2677.

[7]. Bo Yu, Xiangtao Wang, Lijuan Ding, Meihua Han, Yifei Guo*. Hydrophilic natural polylysine as drug nanocarrier for preparation of helical delivery system. Pharmaceutics, 2022, 14, 2512.

[8]. Yifei Guo, Yiping Shen, Bo Yu, Lijuan Ding, Zheng Meng, Xiaotong Wang, Meihua Han, Zhengqi Dong* and Xiangtao Wang*. Hydrophilic poly(glutamic acid)-based nanodrug delivery System: Structural influence and antitumor efficacy. Polymers, 2022, 14, 2242.

[9]. Bo Yu, Yiping Shen, Xuejie Zhang, Lijuan Ding, Zheng Meng, Xiaotong Wang, Meihua Han, Yifei Guo* and Xiangtao Wang*. Poly(methacrylate citric acid) as a dual functional carrier for tumor therapy. Pharmaceutics, 2022, 14, 1765.

[10]. Zhengqi Dong, Xiangtao Wang, Mingyue Wang, Rui Wang, Zheng Meng, Xiaotong Wang, Bo Yu, Meihua Han and Yifei Guo*. Optimization of naringenin nanoparticles to improve the antitussive effects on post-infectious cough. Molecules, 2022, 27, 3736.

[11]. Jingxin Fu, Yian Wang, Haowen Li, Likang Lu, Meihua Han, Yifei Guo and Xiangtao Wang*. A simple but efficient tumor-targeted nanoparticle delivery system constructed by oleic acid. Drug Delivery, 2022, 29(1): 2539.

[12]. Jingxin Fu, Kunfeng Zhang, Likang Lu, Manzhen Li, Meihua Han, Yifei Guo and Xiangtao Wang*. Improved therapeutic efficacy of CBD with good tolerance in the treatment of breast cancer through nanoencapsulation and in combination with 20(S)-protopanaxadiol (PPD). Pharmaceutics, 2022, 14, 1533.

[13]. Hui Ao, Likang Lu, Manzhen Li, Meihua Han, Yifei Guo and Xiangtao Wang*. Enhanced solubility and antitumor activity of annona squamosa seed oil via nanoparticles stabilized with TPGS: Preparation and in vitro and in vivo evaluation. Pharmaceutics, 2022, 14, 1232.

[14]. Hui Ao, Zhuo Wang, Likang Lu, Hongwei Ma, Haowen Li, Jingxin Fu, Manzhen Li, Meihua Han, Yifei Guo and Xiangtao Wang*. Enhanced tumor accumulation and therapeutic efficacy of liposomal drugs through over?threshold dosing. Journal of Nanobiotechnology, 2022, 20: 137.

[15]. Cuiling Zuo, Yuan Zou, Guangyu Gao, Lina Sun, Bo Yu, Yifei Guo, Xiangtao Wang*, Meihua Han,* Photothermal combined with intratumoral injection of annonaceous acetogenin nanoparticles for breast cancer therapy. Colloids and Surfaces B: Biointerfaces, 2022, 213, 112426.

[16]. Zhengqi Dong, Rui Wang, Mingyue Wang, Zheng Meng, Xiaotong Wang, Meihua Han, Yifei Guo,* and XiangtaoWang,* Preparation of naringenin nanosuspension and its antitussive and expectorant effect. Molecules, 2022, 27, 741.

[17]. Jingxin Fu, Yian Wang, Haowen Li, Likang Lu, Hui Ao, Meihua Han, Yifei Guo, and Xiangtao Wang*. A low dose of hydrous icaritin nano-formulation with remarkable efficacy and tumor targeting in cancer therapy. Journal of Biomedical Nanotechnology, 2021, 17, 2003.

[18]. Hui Ao, Hao-Wen Li, Li-Kang Lu, Jing-Xin Fu, Mei-Hua Han, Yi-Fei Guo, and Xiang-Tao Wang*. Sensitive tumor cell line for annonaceous acetogenins and high therapeutic efficacy at a low dose for choriocarcinoma therapy. Journal of Biomedical Nanotechnology, 2021, 17, 2062.

[19]. Jianwei Han, Xinxin Zhou, Jingxin Fu, Guangyu Gao, Cuiling Zuo, Yifei Guo, Meihua-Han*, Xiangtao Wang*. Annonaceous acetogenins nanosuspensions stabilized by poloxamer 188: Preparation, properties and in vivo evaluation. Journal of Drug Delivery Science and Technology, 2021, 66, 102676.

[20]. Yuan Zou, Xiangtao Wang, Dongdong Bi, Jingxin Fu, Jianwei Han, Yifei Guo, Li Feng, Meihua Han. Pterostilbene nanoparticles with small particle size show excellent anti-breast cancer activity in vitro and in vivo. Nanotechnology, 2021, 32, 325102 (9pp).

[21]. Mengying Zhang, Yuan Zou, Cuiling Zuo, Hui Ao, Yifei Guo, Xiangtao Wang, Meihua Han. Targeted antitumor comparison study between dopamine self- polymerization and traditional synthesis for nanoparticle surface modification in drug delivery. Nanotechnology, 2021, 32, 305102 (11pp).

[22]. Haowen Li, Manzhen Li, Jingxin Fu, Hui Ao, Weihua Wang, Xiangtao Wang*. Enhancement of oral bioavailability of quercetin by metabolic inhibitory nanosuspensions compared to conventional nanosuspensions. Drug Delivery, 2021, 28(1): 1226.

[23]. Haowen Li, Yijing Li, Hui Ao, Jingxin Fu, Yifei Guo, Meihua Han, Xueying Yan, Xi Chen* and Xiangtao Wang*. A comparative study on the in vitro and in vivo antitumor efficacy of icaritin and hydrous icaritin nanorods. Drug Delivery, 2020, 27(1): 1176.

[24]. Hui Ao#, Yijing Li#, Haowen Li, Yian Wang, Meihua Han, Yifei Guo, Rongxing Shi*, Feng Yue and Xiangtao Wang*. Preparation of hydroxy genkwanin nanosuspensionsand their enhanced antitumor efficacy against breast cancer. Drug Delivery, 2020, 27(1): 816.

[25]. Tiantian Huang#, Yian Wang# , Yiping Shen, Hui Ao, Yifei Guo, Meihua Han, Xiangtao Wang*. Preparation of High Drug-Loading Celastrol Nanosuspensions and Their Anti-Breast Cancer Activities in Vitro and in Vivo. Scientific Report, 2020, 10(1): 8851.

[26]. Zhengqi Dong, Xiangtao Wang, Shuang Zhao, Hanhong Qiu, Meihua Han, Jingguo Li, Ning Zhao, Rui Wang, Yifei Guo. The influence of nanocarrier architectures on antitumor efficacy of docetaxel nanoparticles. RSC Advances, 2020, 10, 11074.

[27]. Zhengqi Dong, Yiping Shen, Shuang Zhao, Xiangtao Wang, Meihua Han, Ning Zhao, Hui Ao, Yifei Guo*. The influence of hydrophobic chains in nanocarriers on antitumor efficacy of docetaxel nanoparticles. Molecular Pharmaceutics, 2020, 17, 1205.

[28]. Xuejie Zhang#, Xiangtao Wang#, Hanhong Qiu, Dandan Kong, Meihua Han, Yifei Guo*. Poly(methacrylate citric acid) with good biosafety as nanoadsorbents of heavy metal ions. Colloids and Surfaces B: Biointerfaces, 187, 2020, 110656.

[29]. Xuejie Zhang#, Xiangtao Wang#, Hanhong Qiu, Xueqing Sun, Meihua Han, Yifei Guo*.. Nanoadsorbents preparing from oligoethylene glycol dendron and citric acid: Enhanced ad sorption effect for the removal of heavy metal ions. Colloids and Surfaces B: Biointerfaces, 189, 2020, 110876.

[30]. Yian Wang#, Tiantian Huang#, Haowen Li, Jingxin Fu, Hui Ao, Likang Lu, Meihua Han, Yifei Guo, Feng Yue, Xiangtao Wang*. Hydrous icaritin nanorods with excellent stability improves the in vitro and in vivo activity against breast cancer. Drug Delivery, 2020, 27(1): 228.

[31]. Haowen Li#, Biao Liu#, Hui Ao, Jingxin Fu, Yian Wang, Yue Feng, Yifei Guo* and Xiangtao Wang*. Soybean lecithin stabilizes disulfiram nanosuspensions with a high drug-loading content: remarkably improved antitumor efficacy. Journal of Nanobiotechnology, 2020, 18: 4.

[32]. Yifei Guo, Xuejie Zhang, Xueqing Sun, Dandan Kong, Meihua Han, and Xiangtao Wang*. Nanoadsorbents based on NIPAM and citric acid: Removal efficacy of heavy metal ions in different media. ACS Omega, 2019, 4, 14162.

[33]. Qi Xiao-Yu, Liu Hao, Bi Dong-Dong, Wang Xiang-Tao, Guo Yi-Fei, Hao Ting, Zhang Bao-Xin, Wang Xing-Guo,?, Han Mei-Hua?. Combined administration on You-Gui Yin and low-dose Raloxifene partially attenuates the bone loss in ovariectomized mice through the proliferation and osteogenic differentiation of bone marrow stromal cells. Phytomedicine, 2019, 53, 286.

[34]. Zhao Lei, Zhang Mengyinga, Guo Yifei, Wang Xiangtao*, Han Meihua*. Alendronate-modified polydopamine-coated paclitaxel nanoparticles for osteosarcoma-targeted therapy. Journal of Drug Delivery Science and Technology, 2019, 53, 101133.

[35]. Arman Moini Jazani, Newsha Arezi, Chaitra Shetty, Sung Hwa Hong, Haowen Li, Xiangtao Wang and Jung Kwon Oh. Tumor-targeting intracellular drug delivery based on dual acid/reduction-degradable nanoassemblies with ketal interface and disulfide core locations. Polymer Chemistry, 2019, 10, 2840.

[36]. Lei. Zhao#, Dongdong. Bi#, Xiaoyu. Qi, Yifei. Guo, Xiangtao. Wang* and Meihua. Han* Polydopamine-based surface modification of paclitaxel nanoparticles for osteosarcoma targeted therapy. Nanotechnology, 2019, 30(25): 255101.

[37]. Dongdong Bi, Lei Zhao, Haowen Li, Yifei Guo, Xiangtao Wang?, Meihua Han?. A comparative study of polydopamine modified and conventional chemical synthesis method in doxorubicin liposomes form the aspect of tumor targeted therapy. International Journal of Pharmaceutics, 2019, 559: 76.

[38]. Runqi Yu, Yuan Zou, Biao Liu，Yifei Guo, Xiangtao Wang?, Meihua Han?. Surface modification of pH-sensitive honokiol nanoparticles based on dopamine coating for targeted therapy of breast cancer. Colloids and Surfaces B: Biointerfaces, 2019, 177: 1.

[39]. Yifei Guo, Ting Wang, Hanhong Qiu, Meihua Han, Zhengqi Dong?, Xiangtao Wang?, Hydroxycamptothecin nanoparticles based on poly/oligo (ethylene glycol): Architecture effects of nanocarriers on antitumor efficacy. European Journal of Pharmaceutics and Biopharmaceutics, 2019, 134: 178.

授权专利：

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2）王向涛，杨晓凤，韩美华，郭一飞. 一种喜树碱类药物的纳米晶及其制备方法，专利号：ZL201610195547.0

3）王向涛，张明珠，韩美华，郭一飞. 一种雷公藤红素纳米混悬剂及其制备方法，专利号：ZL201610886793.0

4）王向涛，洪靖怡，李艳红，李怡静. 番荔素类药物的纳米混悬剂及制备方法，专利号：ZL201610367608.7

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6）王向涛，李怡静，王一安，敖惠，李好文，韩美华，郭一飞. 一种水和淫羊藿素纳米粒及其制备方法和应用，专利号：ZL201811338149.5

7）王向涛，高艺璇，周欣欣，李好文，敖惠，郭一飞，韩美华. 一种对番荔枝内酯类药物具有增效减毒作用的纳米粒及其制备方法和应用，专利号：ZL201811338300.5

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9）王向涛，刘彪，敖惠，路丽康，李好文. 一种高载药量双硫仑纳米粒及其在肿瘤防治中的应用，专利号：ZL201910170699.9

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11）王向涛，付婧欣，敖惠，郭一飞，韩美华. 一种龙血竭纳米混悬剂及其制备方法，专利号：ZL201910011379.9

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郭一飞

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2）郭一飞，孙雪晴，王向涛. 一种含有甲基丙烯酸2-吗啉基乙酯单体单元的聚合物及应用，专利号：ZL202011110734.7

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4）郭一飞，王明月，董政起，王向涛. 一种以TPGS为载体的柚皮素纳米混悬剂及其制备方法与应用，专利号：ZL202110407188.1

5）郭一飞，沈一平，张雪洁，王向涛，韩美华. 一种以聚柠檬酸为载体的纳米载药颗粒及其制备方法与应用，专利号：ZL202011286955.X

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韩美华