药用植物研究所

孙迪安研究员

男，博士，研究员。团队目前成员2名研究员（孙迪安和丁刚研究员），博士/硕士/联合培养学生8人。主要研究方向：天然活性物质的生物转化、生物合成与真菌次级代谢产物结构与功能。北京市药学会天然药物分会委员，国家自然科学基金一评评审专家，科技部重大创新新药专项评审专家，Journal of Molecular Catalysis B:Enzymatic，Fitoterapia，Journal of Asian Natural products Research 等英文杂志同行评审专家。在包括J. Am. Chem. Soc.; J. Biol. Chem.; Phytochemistry;TetrahedronLetters; J. Chem. Soc., Perkin Trans.1; J. Nat. Prod.;Bioorg. & Med. Chem.; Journal of Molecular Catalysis B:Enzymatic; Fitoterapia等相关专业杂志上发表SCI论文三十多篇。

教育背景

1998.9-2003.5 加拿大,魁北克大学(Université du Québec), 生物学专业,博士.

1989.9-1992.7 中国协和医科大学,药物化学专业,硕士.

1985.9-1989.7 吉林农业大学,药用植物专业,大学本科.

工作经历

2007.7-至今中国医学科学院药用植物研究所研究员（室主任）

2007.1-2007.7 中国医学科学院药用植物研究所助理研究员

2003.6-2006.12 北京费思得生物医药科技发展有限公司 CEO

1998.9-2003.5 　加拿大魁北克大学(Université du Québec)攻读博士学位

1996.11-1998.8 美国佛吉尼亚大学(University of Virginia)化学系访问学者

1992.8-1996.10 中国协和医科大学&中国医学科学院药物研究所

科研情况

从2007年进入药植所成立课题组至今，承担的科研项目共 9 项，其中国家级6 项，省部级1项，其它2项

代表性论文：

Zhao-HuiGao, Ran-Ran Gao，Xin-RanDong , Zhong-Mei Zou, Qi Wang, De-Min Zhou, Di-An Sun*，Selective oxidation-reduction andesterification of asiatic acid by Pestalotiopsismicrosporaand anti-HCV activity, Phytochemistry Letters，2017, 19,108–113
Xin-RanDong, Zhao-Hui Gao, Hong-xiu Hu, Ran-Ran Gao, Di-An Sun*, Microbialtransformation of Pseudoprotodioscin by Chaetomium olivaceum, Journalof Molecular Catalysis B: Enzymatic, 2016, 130, 88-95,
Zhao-HuiGao, Xin-Ran Dong, Ran-Ran Gao, Di-An Sun*, Unusual microbiallactonization and hydroxylation of asiatic acid by Umbelopsis isabellina,Journal of Asian Natural Products Research, 2015,17,1059-1064.
Shao-BinFu, Jun-Shan Yang, Jin-Long Cui, Di-An Sun*, Biotransformation ofursolic acid by Syncephalastrum racemosum CGMCC 3.2500 and anti-HCVactivity, Fitoterapia, 2013, 86, 123-128.
Shao-BinFu, Jun-Shan Yang, Jin-Long Cui, Di-An Sun*, Multihydroxylationof ursolic acid by Pestalotiopsis microspora isolated from the medicinalplant Huperzia serrata, Fitoterapia, 2011,82(7), 1057-1061.
XiaoXiao, Xi-Kui Liu; Shao-Bin Fu; Di-An Sun*, Microbialtransformation of diosgenin by filamentous fungus Cunninghamella echinulata,Journal of Asian Natural Products Research, 2011,13(3),270-275.
冯旭；邹忠梅；储智勇；孙迪安*, 紫杉烷类化合物的生物转化, Chinese Journal of NaturalMedicines, 2011 9(6), 466-472.
Shao-BinFu, Jun-Shan Yang, Di-An Sun*, Biotransformation of Ursolic Acidby an Endophytic Fungus from Medicinal Plant Huperzia serrata, Chemical& Pharmaceutical Bulletin (Tokyo), 2011,59(9), 1180-1182.
XuFeng, Zhong-Mei Zou, Shao-Bin Fu, Ling-Zhi Sun, Zhi-Heng Su, Di-An Sun*, Microbialoxidation and glucosidation of echinocystic acid by Nocardia corallina, Journalof Molecular Catalysis B: Enzymatic, 2010, 66(1-2), 219-223.
XuFeng, Ling-Zhi Sun, Shao-Bin Fu, Zhong-Mei Zou, Di-An Sun*, Microbialtransformation of 7-epi-10-deacetylbaccatin III to 10-deacetylbaccatin III, Journalof Molecular Catalysis B: Enzymatic, 2010, 64(1-2), 45-47.
Di-An Sun, Francoise Sauriol, Orval Mamer,and Lolita O. Zamir; Reanalysis of the biotransformation of4(20),11(12)-taxadiene derivatives, CanadianJournal of Chemistry. 2001, 79, 1381-1393.
Di-An Sun, Anastasia Nikolakakis, Francoise Sauriol, Orval Mamer, Lolita O.Zamir, Microbial and reducing agents catalyze the rearrangement of taxanes. Bioorganic & Medicinal Chemistry, 2001, 9, 1985-1992.
Di-An Sun, Francoise Sauriol, Orval Mamer,and Lolita O. Zamir, Biotransformation of a 4(20), 11(12)-taxadiene derivative,Bioorganic & Medicinal Chemistry.2001, 9, 793-800.
ShanghuiHu, Di-An Sun, A. Ian Scott.An efficient synthesis of 4(5), 11(12)-taxadiene derivatives and microbialmediated 20-hydroxylation of taxoids. TetrahedronLetters. 2000, 41, 1703-1705.
Di-An Sun, Jing-Zhen Deng, Shelley R.Starck, Sidney M. Hecht, Mispyric Acid, a New Monocyclic Triterpenoid with aNovel Skeleton from Mischocarpuspyriformis that Inhibits DNA Polymerase b. J. Am. Chem. Soc., 1999,121,6120-6124.
Di-An Sun, Shelley R. Starck, Edward P.Locke, Sidney M. Hecht. DNA PolymeraseInhibitors from Sandoricum koetjape, Journal of Natural Products. 1999, 62, 1110-1113.